Editing Daiichi Sankyo Company, Limited
The edit can be undone. Please check the comparison below to verify that this is what you want to do, and then publish the changes below to finish undoing the edit.
Latest revision | Your text | ||
Line 102: | Line 102: | ||
The first 2 strategic pillars are outlined below in "'''Products'''". | The first 2 strategic pillars are outlined below in "'''Products'''". | ||
Daiichi Sankyo has several emerging candidates for new growth following 3ADCs. One such driver is the development of DS-7300 which has shown promising durable response in patients with several types of advanced cancer, this is a "first-in-class" B7-H3 directed DXd antibody drug conjugate (ADC), which continues to show promising durable tumour response in patients with several types of heavily pre-treated cancers, including lung, prostate or oesophageal cancer. | Daiichi Sankyo has several emerging candidates for new growth following 3ADCs. One such driver is the development of DS-7300 which has shown promising durable response in patients with several types of advanced cancer, this is a "first-in-class" B7-H3 directed DXd antibody drug conjugate (ADC), which continues to show promising durable tumour response in patients with several types of heavily pre-treated cancers, including lung, prostate or oesophageal cancer. | ||
DS-6000, a CDH6-directed ADC, has also entered development. This drug targets patients with advanced ovarian cancer or renal cell carcinoma. Patients with these diseases have very low survival rates, at 30% and 15% respectively. CDH6 is overexpressed significantly in both of these cancers. Preliminary efficacy results in 20 evaluable patients included six partial responses (50% reduction in tumour size), 12 patients reported with stable disease (Neither increases in size >20%, nor decrease >30%) in platinum-resistant ovarian cancer. Eight CA-125<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764643/#:~:text=CA125%20is%20the%20gold%20standard,progression%20in%20ovarian%20cancer%20patients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764643/#:~:text=CA125%20is%20the%20gold%20standard,progression%20in%20ovarian%20cancer%20patients.]</ref> (gold standard ovarian cancer marker) responses observed in 17 evaluable patients with ovarian cancer.<ref>https://daiichisankyo.us/press-releases/-/article/ds-6000-suggests-early-clinical-activity-in-patients-with-advanced-ovarian-cancer-or-renal-cell-carcinoma</ref> | DS-6000, a CDH6-directed ADC, has also entered development. This drug targets patients with advanced ovarian cancer or renal cell carcinoma. Patients with these diseases have very low survival rates, at 30% and 15% respectively. CDH6 is overexpressed significantly in both of these cancers. Preliminary efficacy results in 20 evaluable patients included six partial responses (50% reduction in tumour size), 12 patients reported with stable disease (Neither increases in size >20%, nor decrease >30%) in platinum-resistant ovarian cancer. Eight CA-125<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764643/#:~:text=CA125%20is%20the%20gold%20standard,progression%20in%20ovarian%20cancer%20patients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764643/#:~:text=CA125%20is%20the%20gold%20standard,progression%20in%20ovarian%20cancer%20patients.]</ref> (gold standard ovarian cancer marker) responses observed in 17 evaluable patients with ovarian cancer.<ref>https://daiichisankyo.us/press-releases/-/article/ds-6000-suggests-early-clinical-activity-in-patients-with-advanced-ovarian-cancer-or-renal-cell-carcinoma</ref> |