Editing Daiichi Sankyo Company, Limited
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T-DXd is an ADC that uses the HER-2 targeted antibody trastuzumab to deliver a cytotoxic payload selectively to HER2-expressing cells. In the DESTINY-Breast01 phase II clinical trial, T-DXd showed clinical activity in the third-line setting for patients with HER2-positive metastatic breast cancer, these results led to accelerated approval of T-DXd in 2019 as a third-line therapy for patients with metastatic or unresectable breast cancer who have received two or more prior HER2-targeted therapies.<ref>https://www.aacr.org/about-the-aacr/newsroom/news-releases/t-dxd-yields-superior-outcomes-over-chemotherapy-based-regimens-in-patients-previously-treated-with-t-dm1/</ref> | T-DXd is an ADC that uses the HER-2 targeted antibody trastuzumab to deliver a cytotoxic payload selectively to HER2-expressing cells. In the DESTINY-Breast01 phase II clinical trial, T-DXd showed clinical activity in the third-line setting for patients with HER2-positive metastatic breast cancer, these results led to accelerated approval of T-DXd in 2019 as a third-line therapy for patients with metastatic or unresectable breast cancer who have received two or more prior HER2-targeted therapies.<ref>https://www.aacr.org/about-the-aacr/newsroom/news-releases/t-dxd-yields-superior-outcomes-over-chemotherapy-based-regimens-in-patients-previously-treated-with-t-dm1/</ref> | ||
ENHERTU® is approved in over 30 countries for treatment of adult patients with unresectable or metastatic HER2 positive breast cancer. | An example of a highly successful T-DXd drug from the company is ENHERTU®, which is approved in over 30 countries for treatment of adult patients with unresectable or metastatic HER2 positive breast cancer. | ||
A list of T-DXd drugs currently in clinical trials can be found [https://www.daiichisankyo.com/files/rd/pipeline/index/pdf/pipeline2304_en.pdf here] in orange. | A list of T-DXd drugs currently in clinical trials can be found [https://www.daiichisankyo.com/files/rd/pipeline/index/pdf/pipeline2304_en.pdf here] in orange. |