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== Cellular agriculture explained == Cellular agriculture refers to the process of deriving conventional agricultural products directly from cell culture and fermentation, without the need for animals. This encompasses the concepts of cultivated meat, precision fermentation and the utilisation of microorganisms to grow animal-derived ingredients. Cellular agriculture includes cultivated meat, which is created by painlessly harvesting stem cells from an animal. The cells are then placed in bioreactors and fed growth proteins, carbohydrates, vitamins and minerals, so they multiply to create the desired cell type, including muscle and fat tissue, which are the main components of the meat we consume. The tissue is biologically equivalent to the meat tissue that comes from the original animal. The typical time spent in the bioreactor depends on the species but is much shorter than conventional livestock farming: beef cells take c 30 days to mature compared to around 24 months via conventional farming, while chicken cells take one to two weeks compared to the usual 12–16 weeks. The key difference from plant-based proteins, which is likely to make cultivated meat much more attractive to consumers, is that cultivated meat is equivalent to normal meat at the molecular level, thus providing the same taste and nutritional profile as traditional meat. '''Exhibit 2: Cellular agriculture process''' [[File:Cellular agriculture process.png|600px]] Source: Edison Investment Research === Creating a structure via 3D bioprinting === The alternative meat market is becoming increasingly crowded, particularly on the plant-based side, as discussed above. Until now, however, offerings have largely been alternatives to minced meat products such as beef patties/burgers or chicken nuggets. The reason for this is that the fibrous texture and visual appearance of ‘structured’ meats such as a chicken breast or a sirloin steak are very hard to replicate. 3D printing is being used by several companies to create the fibrous structure and MeaTech is among these. MeaTech’s process uses its purified cultured cells to formulate bio-inks. These are then loaded with edible scaffolding materials into a 3D bioprinter and printed to create a cell structure as would be found in a conventional cut of meat. At scale, the printing process should be quick, taking a few minutes at most, depending on size and complexity of the cut. The printed cut of meat is then sent to an incubator to mature. The incubation period varies depending on the final product but is typically no longer than two to three weeks. MeaTech has a number of patents pending to cover its production process. It is using lab-scale bioreactors to produce its muscle and fat cells and is working towards pilot scale production. In December 2021, MeaTech 3D reported a breakthrough with the printing of a 3.67oz (104g) cultivated steak consisting of real, living muscle and fat tissues, without utilising any soy or pea protein. Management believes this is the largest cultivated steak produced to date. The company plans to have a demo facility for beef products within the next two to three years and to commence the design and potentially the building of a pilot plant for cultured chicken fat production in 2022. Edison Investment Research notes that MeaTech is also working on hybrid products, whereby cultured fat cells are added to plant-based protein to create meatier textures that are generally preferred by consumers. '''Exhibit 3: MeaTech’s cultured steak vision''' [[File:MeaTech’s cultured steak vision.png|600px]] Source: MeaTech 3D. === Peace of Meat: The hybrid opportunity === MeaTech began its R&D with beef cultured products and acquired Peace of Meat (POM) in February 2020. POM is based in Belgium and focuses on avian products, s`pecifically cultured chicken fat. The acquisition of POM enabled MeaTech to accelerate its commercialisation plans as POM was slightly more advanced in terms of its scale-up. In addition, POM broadened MeaTech’s cell lines and the number of species it can grow, as POM has a non-GMO immortal chicken cell line that grows in suspension. Cultured chicken fat has a large potential market in hybrid products, as mentioned above and can be used together with plant-based materials to recreate a more convincing ‘meaty’ texture and taste. Hybrid products are a useful steppingstone towards the creation of fully cultured meat, both in terms of technical challenges and cost. === The opportunities and challenges of cellular meat === Over the last few years, there has been significant progress in producing cultivated meat. In terms of the product, while taste is of paramount importance, texture and appearance are also essential to the consumer experience, as discussed above. The overwhelming advantage of cultured meat is the fact that it is biologically identical to conventional meat while its use of resources is substantially lower. At present, most production processes are still operating at lab scale. Cost remains a major hurdle, with the growth medium proving to be the most expensive part of the process, although this is expected to decline as volumes grow. Regulation is also a barrier, as cultivated food requires approval in most jurisdictions, in some cases by several regulatory bodies (eg in the United States approval for cultivated meat is required by both the US Department of Agriculture (USDA) and the Food and Drug Administration (FDA)). At present, Singapore is the only jurisdiction globally where cultivated meat is approved for sale, with chicken being the first meat available to Singaporean consumers, although currently only in a single restaurant. There are a number of companies which are active in the cultured meat space, though limited information is available as they are privately held. There are also a number of companies involved in 3D printing, with some choosing to 3D print plant-based steaks (eg Redefine Meat’s 3D printed plant-based meats are being sold in high end restaurants in several countries in Europe). While products are still either at the prototype stage or selectively distributed, it is impossible to judge how consumers will react to the various competing products. MeaTech’s intention to recreate a steak by 3D printing should place it in good stead compared to conventional alternatives, assuming the taste, texture, aroma and overall consumer experience are comparable to that of conventional steak. This of course also assumes all regulatory hurdles are cleared and the cost is at a level that is acceptable to the consumer. === Resource use === Conventional livestock farming is well-known for causing carbon emissions and for its use of land, water and energy. In contrast, cellular agriculture is much less resource-intensive. For example, each kilogram of conventional farmed meat produces on average 14kg of CO2 emissions, versus 3kg for cultured meat (source: MeaTech). '''Exhibit 4: Resource use of conventionally farmed beef compared to cultured beef''' [[File:Resource use of conventionally farmed beef compared to cultured beef.png|600px]] Source: MeaTech 3D, Edison Investment Research In addition, while conventional farming of livestock and fish uses most of the antibiotics produced worldwide, cellular agriculture requires minimal or no antibiotics. Food safety is also improved with cultured meat, due to the absence of mass slaughtering and the clean environment in which the cells are cultured. This reduces the likelihood of contamination from pathogens such as salmonella or E. coli and also results in the benefit of a longer shelf life for the finished product. '''Scale''' Cell culture and fermentation have been used for the last 20–30 years in the healthcare sector. Cellular agriculture for food production is a relatively new concept and the technology is still developing. At present, cellular agriculture is mostly being undertaken in labs (with quantities below 1000L), and therefore requires scaling up to pilot stage (c 5,000L), and then full commercial production (>20,000L), in order to reduce costs and manufacture meaningful quantities. Scaling up always presents challenges, both predictable and unforeseen, as the different conditions need to be optimised. One of the problems when it comes to scaling up cell culture is the increased pressure in the larger bioreactors, particularly at the bottom. If the bioreactors are too large, this pressure can cause damage to the cell structure, thereby causing the process to break down. Unless a workaround can be found, this could ultimately limit the size of the largest bioreactors that can be used on a commercial scale, which in turn would be likely to have cost implications in the long run. Similarly, processes may need to be adapted as cellular agriculture moves to commercial scale. Extending the technology from one type of cell/product to the next is also far from straightforward, as each different cell line is likely to require a different growth medium and particular growing conditions. Purification of the cells from the ‘soup’ in the bioreactor may also differ. Lastly, the scale-up phase may present different challenges depending on the various characteristics of each type of cell. As discussed above, MeaTech plans to have a demo facility for beef products within the next two to three years. A cultured chicken fat pilot plant is also expected in this timeframe. In September 2021, MeaTech announced that it had manufactured over 500g of cultivated fat biomass in a single production run, and, as discussed above, in December 2021 it announced it had printed 3.67oz (104g) of cultured steak. '''Cost''' Currently the main cost challenge within cellular agriculture is the cost of the growth medium, which needs to be optimised for each cell line. At present, most growth media are available in lab-scale quantities only, thus making them cost-prohibitive on an industrial scale. For obvious reasons, both the specific characteristics of cell lines and the growth media they require are considered commercially sensitive and proprietary information, therefore there is not much public information available. In February 2020, the Good Food Institute (GFI) published a paper in which it estimated that the cost per litre for standard growth medium was $377, which translated to a cost per kg of meat of c $8,600. The paper discusses various scenarios under which this could be improved, including reducing the concentration of certain ingredients (by optimising the process), replacing some ingredients with cheaper alternatives, and reducing procurement costs by improving sourcing. In addition, the bio-fermentation process could improve and thus require a lower average volume of medium. The GFI estimated that under the most optimistic scenario, the cost per litre would fall to $0.24, allowing the cost per kg of meat to fall to $1.37 (the two main drivers of this being reducing the concentration of the growth factors required and scaling up the two most expensive ones such that their cost is significantly reduced). The much-touted number in the alternative protein industry is the cost of the first cultivated meat burger, which is placed at around €250,000 (it was developed by a Dutch scientist in 2013, although the CEO of Mosa Meat has subsequently stated that the real number is ‘a bit higher’). The cost has come down significantly but, for the product to become a viable alternative to conventional meat, something in the region of cost parity is required. As Nick Halla, senior VP International at Impossible Foods, has said, ‘you’ll buy the product once based on novelty, you’ll come back if the taste is good and if there are benefits such as nutrition and sustainability, and you’ll buy it in the long run if the value is right.’ The other side of the equation in terms of achieving anything close to price parity is the cost of conventional meat. Edison Investment Research notes that COVID-19 has driven up prices as the meat industry in many regions has suffered from labour shortages and increased freight costs. As concerns regarding climate change and sustainability come to the fore, Edison Investment Research could see governments start to reduce some farming subsidies or indeed introduce some form of taxation on carbon emissions caused by farming. This would cause cost increases for conventionally farmed produce. '''Regulation''' As discussed above, cultivated meat is not currently approved for sale in any jurisdiction apart from Singapore. That said, as cellular agriculture becomes closer to commercial viability, Edison Investment Research would expect more regulators to examine and approve the product. Edison Investment Research notes that regulation changes by jurisdiction, but also by product: for example, cultivated seafood would only require approval by the FDA in the United States, while cultivated meat requires both FDA and USDA approval in the United States. Edison Investment Research notes that in the EU, approval would be required both by the European Food Safety Authority via the Novel Food Regulation and individual countries. Furthermore, approval will be required for each different product and, potentially, using different components (such as edible scaffolds) would require a new safety review each time. Farming lobbies are powerful worldwide, especially in the United States and the EU. Edison Investment Research would expect farmers to lobby aggressively against the approval of cellular agriculture, and potentially try and dissuade consumers from switching to cultivated food.
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