Open main menu
Home
Random
Donate
Recent changes
Special pages
Community portal
Preferences
About Stockhub
Disclaimers
Search
User menu
Talk
Contributions
Create account
Log in
Editing
Oncolytics Biotech Inc.
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
== Product<ref>https://pubmed.ncbi.nlm.nih.gov/25693885/</ref> == Oncolytics’ core product is '''Pelareorep,''' a cutting-edge intravenously delivered immunotherapeutic agent aiming to treat solid tumours and hematological malignancies'''.''' Oncolytics Biotech. is testing Pelareorep as a potential treatment as the immune system has difficulty recognising and destroying malignant cancerous cells. It can be used alone or for more successful results, in combination with other chemotherapeutic drugs such as Paclitaxel<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923331/</ref>, or immunotherapies such as CAR T, targeting a large market audience. Cancer cells (tumour cells) are unique in comparison to other cells in the body as they can rapidly multiply due to their ability to carry out a cell signalling pathway, namely the '''RAS-activated pathway'''<ref>https://doi.org/10.1016/B978-0-12-394295-1.00013-5</ref>. As a proprietary isolate of the naturally occurring, non-pathogenic double-stranded RNA (dsRNA) virus reovirus, Pelareorep can target this pathway. '''Reoviruses''' are a group of RNA double stranded viruses possessing the ability to recognise unique glycans on cancerous cells via the σ1R protein to allow immune system enhancement. The RAS-activated pathway required for Pelareorep to function is only present in cancerous cells, this includes some of the most common cancers such as lung and breast cancer. Its mechanism of action involves the activation of both the innate and adaptive immune systems while weakening tumor defense mechanisms<ref>https://www.oncolyticsbiotech.com/technology/posters-publications</ref>. This effect enhances the immune system's ability to combat cancer, rendering tumors more susceptible to a diverse range of oncology treatments. Pelareorep is injected intravenously, once it interacts with a RAS-activated cancer cells it rapidly multiplies which causes: * Release of cytokines (innate) * Activation of Natural Killer cells (innate) * Dendritic cell activation (innate) * '''T cell education and activation'''<ref>https://d1io3yog0oux5.cloudfront.net/_8c13c7b0608db4d5d85624e790b574c9/oncolyticsbiotech/db/343/2603/pdf/2022+AWARE-1+SITC+Final.pdf</ref> (adaptive) * Tumour cell lysis * Activation of the interferon-gamma (IFN-γ) signalling pathway After the cell has burst all of the daughter Pelareorep cells are released to continue the process in surrounding cancer cells with the same glycans, until all cancerous cells have been defeated. The Oncolytic Virus Therapy market is projected to experience substantial growth, with an estimated value of USD 29 million by 2028, compared to its previous value of USD 6 million in 2021. The market is expected to grow at a compound annual growth rate (CAGR) of 24.9% from 2022 to 2028<ref>https://www.marketwatch.com/press-release/oncolytic-virus-therapy-market-demand-share-report-2023-2030-2023-05-22</ref>. Pelareorep has been clinically tested in partnership with Canadian Cancer Trials Group for pancreatic, breast, head, neck, prostate, lung, colorectal, bladder and ovarian cancers. Breast and pancreatic cancer tests have shown statistically significant results and have moved to Phase III clinical trials, on track for licence enabling studies. The clinical tests have also shown '''low death rates and less adverse side effects''' in comparison to chemotherapy. Side effects are: chills, fever, headache, cough, myalgia, runny nose, sore throat, fatigue, lymphopenia or neutropenia all for less than 6 hours. The use of Pelareorep withholds many competitive advantages including: * Intravenous delivery which quickly targets metastatic cells * Pelareorep does not require special handling to be used, it follows a simple procedure * Selectively destroys tumour cells, not normal, healthy cells * It has a predictive biomarker- peripheral T-cell clonality Pelareorep is manufactured at a commercial scale under a commercial supply agreement with '''MilliporeSigma''' (formerly Sigma-Aldrich)<ref>https://www.oncolyticsbiotech.com/technology/manufacturing</ref>. Currently, Pelareorep is mainly supplied to Canada and the US, however the company is looking to expand to other countries with 17 pending patent applications. Currently the price of Pelareorep is unknown as it isn't officially a marketed drug, but it is likely to be equivalent to the price of Pfizer's Paclitaxel at '''$18 for a supply of 5 millilitres.'''
Summary:
Please note that all contributions to Stockhub may be edited, altered, or removed by other contributors. If you do not want your writing to be edited mercilessly, then do not submit it here.
You are also promising us that you wrote this yourself, or copied it from a public domain or similar free resource (see
Stockhub:Copyrights
for details).
Do not submit copyrighted work without permission!
Cancel
Editing help
(opens in new window)