Open main menu
Home
Random
Donate
Recent changes
Special pages
Community portal
Preferences
About Stockhub
Disclaimers
Search
User menu
Talk
Contributions
Create account
Log in
Editing
Scandion Oncology
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
=== Two shots on goal for SCO-101 === Scandion Oncology’s clinical development strategy for SCO-101 revolves around two clinical studies: CORIST (NCT04247256) and PANTAX (NCT04652206) (Exhibit 1). Of these, the Phase II CORIST trial is the most advanced and aims to demonstrate proof-of-concept for SOC-101 in patients with mCRC in combination with FOLFIRI (folinic acid + fluorouracil + irinotecan). Colorectal cancer represents the third leading cause of cancer-related deaths in the United States. Colorectal cancer has an estimated incidence rate of 0.0039% in the United States. In 2020 915,880 people worldwide died from the disease and it is expected that a further 52,580 people in the United States will die from the disease in 2022. At diagnosis, c 20% of patients will have mCRC and five-year survival of patients with mCRC is only 20%, representing a clear unmet medical need. '''Exhibit 1: SCO-101 development strategy'''<ref>Source: Scandion Oncology interim report Q122.</ref> [[File:Image3-f037ec1ee2495554a573c0cdde896311.png|600px]] The market for CRC treatment is estimated to reach $8.7bn by 2028 (EvaluatePharma) and, since Avastin (bevacizumab, Roche) went off-patent in 2019, has become more fragmented (see Exhibit 2). This market represents an attractive opportunity for SCO-101, in Edison Investment Research's view, as Edison believes Scandion could potentially establish market share for its product candidates more easily compared to indications that are dominated by one or two therapies. Additionally, many treatments for CRC (including mCRC) are already off-patent, for example irinotecan and 5-fluorouracil (the active ingredients of FOLFIRI). Edison Investment Research believes this will motivate Scandion to pursue premium pricing for SCO-101 as it would generally be used in combination with relatively inexpensive drugs. '''Exhibit 2: Estimated CRC market to 2028'''<ref name=":0">Source: EvaluatePharma, Edison Investment Research.</ref> [[File:Image4-6ff227f569067ae2b29573f4aa4f3314.png|600px]] '''Exhibit 3: Estimated PC market to 2028<ref name=":0" />''' [[File:Image5-ca177f6ef17ee0c8dfa1ecbf0e399de9.png|600px]] The second trial, PANTAX, is a Phase Ib study investigating the safety and tolerability of SCO-101 in patients with unresectable or metastatic PC as an add-on to treatment with nab-paclitaxel and gemcitabine. PC accounts for only 3% of all cancers but 7% of cancer-related deaths, due to the disease’s invasive and often incurable nature. Accordingly, the five-year survival rate for patients with PC is only 11%, dropping to 3% for patients who are diagnosed after the disease has metastasised. The PC treatment market is estimated to reach $5.3bn by 2028 (source: EvaluatePharma). However, Merck’s Keytruda (pembrolizumab) is expected to dominate the market in this period (consensus worldwide sales in 2028 of $2.7bn). Edison Investment Research notes that, as in CRC, many standard PC treatments are off-patent (eg nab-paclitaxel) and if SCO-101 can restore clinical response to these (eg nab-paclitaxel), Edison Investment Research sees an sizable opportunity for Scandion Oncology in this market.
Summary:
Please note that all contributions to Stockhub may be edited, altered, or removed by other contributors. If you do not want your writing to be edited mercilessly, then do not submit it here.
You are also promising us that you wrote this yourself, or copied it from a public domain or similar free resource (see
Stockhub:Copyrights
for details).
Do not submit copyrighted work without permission!
Cancel
Editing help
(opens in new window)