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Scandion Oncology
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=== Partnership deal will be key for development === The company awaits an important proof-of-concept readout from part 2 of the Phase II CORIST clinical trial in mCRC, which is expected in mid-2022. Success in CORIST will be key in establishing proof-of-concept and advancing it to subsequent trials. Edison Investment Research notes that CORIST is an open-label study and Edison Investment Research believes potential global big pharma partners will prefer randomised data before considering in-licensing, meaning further clinical studies will likely be necessary, in its view, to maximise the value of SCO-101. Assuming positive data from CORIST part 2, Edison Investment Research anticipates management will raise additional capital to fund randomised trial (likely Phase II) thus building the data package needed to engage global big pharma partners. ==== IP position encouraging ==== Around 20 years ago, SCO-101 (then known as endovion) was a clinical compound under investigation for the treatment of sickle cell anaemia and was owned by Danish biotechnology company NeuroSearch. The drug was discontinued after Phase I trials. Subsequently, Scandion Oncology was formed in 2017 after initial investigations indicated the compound as a potential add-on therapy to overcome cancer resistance. Scandion now possesses a large intellectual property estate on SCO-101, which it is continuously expanding. Importantly, the company has market protection for the treatment of cancers with SCO-101 in combination with other anti-cancer agents until 2037 in Europe (EP3458052B and EP3622953B) and 2038 in the US (US11,103,481). Edison Investment Research sees this as a positive position for Scandion as it will (assuming the potential launch of SCO-101 in CRC in 2026) allow for over 10 years of market protection in Europe and the United States.
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